Infertility - An Overview

What Is Infertility?

Causes Of Infertility

Infertility can be due to factors in either the female or the male (fig. 1, fig. 2). 35-40% of the time the cause can be traced to the female partner, and 35-40% of the time infertility can be linked to the male partner. Sometimes conditions in both partners play a role. Other times the reason for infertility remains unknown.

figure 1	figure 2

Common Causes For Women

• Impaired ovulation due to disease, birth defects, or abnormal hormone production
• Blocked fallopian tubes from infection or scar tissue
• Inability of the uterus to hold the embryo (this may be due to a variety of reasons, including scar tissue on the walls of the uterus)
  
• Endometriosis

Common Causes For Men

• Low sperm count
• High percent of abnormally shaped sperm
• High percent of sperm that are not moving forward
• Ejaculation dysfunction

When To See A Doctor

Most physicians will recommend that couples try to conceive for a year before seeking medical assistance. If a woman is over 30, has a history of pelvic disease, miscarriage, painful menstruation, irregular cycles, or if her partner has a low sperm count, the National Infertility Association recommends that she and her partner may want to seek professional advice sooner.

Testing For Infertility

Tests may include:

Tests to evaluate male causes:

• Semen analysis to evaluate ejaculate; the specimen is collected after 2 to 3 days of complete abstinence to determine volume and viscosity of semen and sperm count, motility, swimming speed, and shape.
• Postcoital test (PCT) -- to evaluate sperm-cervical mucus interaction through analysis of cervical mucus collected 2 to 8 hours after the couple has intercourse.
• Testicular biopsy (rarely done).

Tests to check for how well a woman’s ovaries are functioning:

• Measuring basal body temperature -- a woman takes her temperature each morning to track the changes in body temperature associated with ovulation.
• Monitoring cervical mucus changes throughout the menstrual cycle to note the wet, stretchy, and slippery mucus associated with the ovulatory phase.
• Measuring serum progesterone (blood test).
• Endometrial biopsy.
• Measuring urinary luteinizing hormone by using kits commercially available for home use to predict ovulation and assist with timing of intercourse.
• Serum hormonal levels (blood tests) for either or both partners.

Tests to make sure a woman uterus and tubes are working:

• Hysterosalpingography (HSG) -- an X-ray procedure done with contrast dye that outlines the uterus and tubes, making sure there is a clear path for sperm traveling to meet the egg.
• Hysteroscopy -- an office procedure that guides a small camera into the uterus, allowing the doctor to see problems with the lining of the uterus that may contribute to infertility.
• Laparoscopy to allow direct visualization of the pelvic cavity.
• Progesterone challenge test -- to check to make sure the lining of the uterus is functioning normally.

Treatments

Treatment depends on the cause of infertility for any given couple. It may include simple education and counseling, the use of medications that treat infections or promote ovulation, or highly sophisticated medical procedures such as n-vitro fertilization.

It is important for the couple to recognize and discuss the emotional impact of infertility, and to seek medical advice from a health care provider. Support groups for infertile couples may be an important source of strength and comfort. RESOLVE, a national organization, both provides informal support and serves as a referral base for professional counseling specific to infertility issues.

Review Date: 2/20/2007
Reviewed By: Douglas A. Levine, MD, Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, NY. Review provided by VeriMed Healthcare Network.

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